Induced pluripotent stem cell-derived vascular smooth muscle cells
نویسندگان
چکیده
منابع مشابه
Differentiation and Application of Induced Pluripotent Stem Cell-Derived Vascular Smooth Muscle Cells.
Vascular smooth muscle cells (VSMCs) play a role in the development of vascular disease, for example, neointimal formation, arterial aneurysm, and Marfan syndrome caused by genetic mutations in VSMCs, but little is known about the mechanisms of the disease process. Advances in induced pluripotent stem cell technology have now made it possible to derive VSMCs from several different somatic cells...
متن کاملDifferentiation and Application of Induced Pluripotent Stem Cell–Derived Vascular Smooth Muscle Cells
Smooth muscle cells (SMCs) form part of a large network of nonstriated muscle that extends from the inner lining of hollow organs, such as the intestinal and respiratory tracts, to the central layers of all major blood vessels. To this end, SMCs can fulfill their role by ensuring synchronized, unidirectional movement of the organ’s contents. Vascular smooth muscle cells (VSMCs) are the SMC popu...
متن کاملVascular Smooth Muscle Cells From Hypertensive Patient-Derived Induced Pluripotent Stem Cells to Advance Hypertension Pharmacogenomics.
UNLABELLED Studies in hypertension (HTN) pharmacogenomics seek to identify genetic sources of variable antihypertensive drug response. Genetic association studies have detected single-nucleotide polymorphisms (SNPs) that link to drug responses; however, to understand mechanisms underlying how genetic traits alter drug responses, a biological interface is needed. Patient-derived induced pluripot...
متن کاملFunctional vascular smooth muscle cells derived from human induced pluripotent stem cells via mesenchymal stem cell intermediates.
AIMS Smooth muscle cells (SMC) play an important role in vascular homeostasis and disease. Although adult mesenchymal stem cells (MSC) have been used as a source of contractile SMC, they suffer from limited proliferation potential and culture senescence, particularly when originating from older donors. By comparison, human induced pluripotent stem cells (hiPSC) can provide an unlimited source o...
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In addition to its antioxidant effect, Vitamin E or α–tocopherol is suggested to enhance remyelination in the animal model of non-inflammatory demyelination. In this study, the possible proliferative effect of vitamin E on human- induced pluripotent stem cell-derived neural progenitors (hiPS-NPs) and the underlying mechanisms were investigated in vitro. NPs were induced from iPS cells via 3 ste...
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ژورنال
عنوان ژورنال: Vascular Biology
سال: 2020
ISSN: 2516-5658
DOI: 10.1530/vb-19-0028